Vitamin D supplements for prevention of tuberculosis infection and disease

Vitamin D and chronic disease prevention.

Clinical trials of vitamin and mineral supplements for cancer prevention.

Approximately 20-30% of Americans consume multivitamin supplements daily, indicating high public interest in the prevention of cancer and other chronic diseases through a nutrition-based approach. Although several bioactive food components, including vitamins and minerals, have been investigated for their ability to affect cancer risk, few large, randomized, placebo-controlled clinical trials o...

Vitamin D and tuberculosis.

Tuberculosis is highly prevalent worldwide, accounting for nearly two million deaths annually. Vitamin D influences the immune response to tuberculosis, and vitamin D deficiency has been associated with increased tuberculosis risk in different populations. Genetic variability may influence host susceptibility to developing active tuberculosis and treatment response. Studies examining the associ...

Vitamin D and tuberculosis.

Coussens et al. reported an analysis of markers of immune and inflammatory response in a subset of participants from a randomized clinical trial of vitamin D3 supplementation in culturepositive pulmonary tuberculosis (1). In that trial, the vitamin D intervention did not alter the primary endpoint, time to sputum culture conversion (2), a result that is congruent with that from another randomiz...

Vitamin D and Tuberculosis

Tuberculosis (TB) remains a major global healthcare issue. The incidence of TB in sub-Saharan Africa is around 350 per 100,000, compared with an incidence of 50 per 100,000 in Europe and approximately 231/100000 in Pakistan. Around 1.7 million people died in 2009 due to TB and the absolute number of cases rises each year due to increasing global population. The emergence of drug resistance, wor...